Aspartoacylase Deficiency in the White Matter of Human Immunodeficiency Virus Encephalitis: Novel Mechanism in Axonal Damage | Zendy

Sankar Surendran | Zendy; Srinivasagam Rajasankar | Zendy

Open Access

Aspartoacylase Deficiency in the White Matter of Human Immunodeficiency Virus Encephalitis: Novel Mechanism in Axonal Damage

Author(s) -

Sankar Surendran,

Srinivasagam Rajasankar

Publication year - 2011

Publication title -

pathology research international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.398

H-Index - 21

eISSN - 2090-8091

pISSN - 2042-003X

DOI - 10.4061/2011/426058

Subject(s) - white matter , myelin , immunostaining , western blot , pathology , encephalitis , human immunodeficiency virus (hiv) , medicine , virus , virology , immunology , biology , central nervous system , neuroscience , immunohistochemistry , magnetic resonance imaging , genetics , gene , radiology

Aspartoacylase/aminoacylase II (ASPA/ACY II) is mainly synthesized in oligodendrocytes to contribute in myelin synthesis. Although axonal damage is seen in the brain with human immunodeficiency virus encephalitis (HIVE), ASPA contribution in the pathology is not known. Immunostaining study showed that ASPA protein is reduced in the white matter of patients with HIVE compared to the control. Western blot study further confirmed ASPA deficiency in the HIVE brain compared to the control. This paper suggests that HIVE condition affects ASPA to contribute in myelin loss/axonal damage seen in the disease

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