Recent Advances in Molecular Diagnosis of Thyroid Cancer | Zendy

Ioannis Legakis | Zendy; Konstantinos Syrigos | Zendy

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Recent Advances in Molecular Diagnosis of Thyroid Cancer

Author(s) -

Ioannis Legakis,

Konstantinos Syrigos

Publication year - 2011

Publication title -

journal of thyroid research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 31

eISSN - 2090-8067

pISSN - 2042-0072

DOI - 10.4061/2011/384213

Subject(s) - thyroid cancer , medicine , thyroid , carcinogenesis , cancer , thyroid carcinoma , cancer research , pathogenesis , bioinformatics , disease , pi3k/akt/mtor pathway , pathology , biology , genetics , signal transduction

Recent molecular studies have described a number of abnormalities associated with the progression and dedifferentiation of thyroid carcinoma. These distinct molecular events are often associated with specific stages of tumor development. In particular, remarkable advances have occurred in several major biological areas of thyroid cancer, including the molecular alterations for the loss of radioiodine avidity of thyroid cancer, the pathogenic role of the MAP kinase and PI3K/Akt pathways and their related genetic alterations, and the aberrant methylation of functionally important genes in thyroid tumorigenesis and pathogenesis. Recognition of these features is crucial to the management of patients with thyroid cancer. Novel treatments are being designed based on our enhanced understanding of this disease process

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