Acid Phosphatases of Budding Yeast as a Model of Choice for Transcription Regulation Research
Author(s) -
Elena V. Sambuk,
A. Yu. Fizikova,
Vladimir A. Savinov,
Marina V. Padkina
Publication year - 2011
Publication title -
enzyme research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.439
H-Index - 39
eISSN - 2090-0406
pISSN - 2090-0414
DOI - 10.4061/2011/356093
Subject(s) - phosphatase , yeast , regulator , budding yeast , saccharomyces cerevisiae , biology , kinase , gene , transcription (linguistics) , transcriptional regulation , master regulator , cyclin , microbiology and biotechnology , phosphorylation , genetics , transcription factor , cell cycle , linguistics , philosophy
Acid phosphatases of budding yeast have been studied for more than forty years. This paper covers biochemical characteristics of acid phosphatases and different aspects in expression regulation of eukaryotic genes, which were researched using acid phosphatases model. A special focus is devoted to cyclin-dependent kinase Pho85p, a negative transcriptional regulator, and its role in maintaining mitochondrial genome stability and to pleiotropic effects of pho85 mutations
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