Protein Kinases and Phosphatases in the Control of Cell Fate | Zendy

Angela Boi | Zendy; Chiara Agnoletto | Zendy; Elena De Marchi | Zendy; Saverio Marchi | Zendy; Simone Patergnani | Zendy; Massimo Bonora | Zendy; Carlotta Giorgi | Zendy; Sonia Missiroli | Zendy; Federica Poletti | Zendy; Alessandro Rimessi | Zendy; Paolo Pinton | Zendy

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Protein Kinases and Phosphatases in the Control of Cell Fate

Author(s) -

Angela Boi,

Chiara Agnoletto,

Elena De Marchi,

Saverio Marchi,

Simone Patergnani,

Massimo Bonora,

Carlotta Giorgi,

Sonia Missiroli,

Federica Poletti,

Alessandro Rimessi,

Paolo Pinton

Publication year - 2011

Publication title -

enzyme research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.439

H-Index - 39

eISSN - 2090-0406

pISSN - 2090-0414

DOI - 10.4061/2011/329098

Subject(s) - kinase , phosphorylation , phosphatase , microbiology and biotechnology , pten , pi3k/akt/mtor pathway , protein phosphorylation , protein kinase b , mitogen activated protein kinase , biology , protein kinase a , signal transduction

Protein phosphorylation controls many aspects of cell fate and is often deregulated in pathological conditions. Several recent findings have provided an intriguing insight into the spatial regulation of protein phosphorylation across different subcellular compartments and how this can be finely orchestrated by specific kinases and phosphatases. In this review, the focus will be placed on (i) the phosphoinositide 3-kinase (PI3K) pathway, specifically on the kinases Akt and mTOR and on the phosphatases PP2a and PTEN, and on (ii) the PKC family of serine/threonine kinases. We will look at general aspects of cell physiology controlled by these kinases and phosphatases, highlighting the signalling pathways that drive cell division, proliferation, and apoptosis.

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