Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India | Zendy

Veena Rao | Zendy; Radhika K. Nagaraj | Zendy; Sridhara Hebbagodi | Zendy; Natesha B. Kadarinarasimhiah | Zendy; Vijay V. Kakkar | Zendy

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Association of Inflammatory and Oxidative Stress Markers with Metabolic Syndrome in Asian Indians in India

Author(s) -

Veena Rao,

Radhika K. Nagaraj,

Sridhara Hebbagodi,

Natesha B. Kadarinarasimhiah,

Vijay V. Kakkar

Publication year - 2010

Publication title -

cardiology research and practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 35

eISSN - 2090-8016

pISSN - 2090-0597

DOI - 10.4061/2011/295976

Subject(s) - medicine , metabolic syndrome , oxidative stress , neopterin , proinflammatory cytokine , disease , population , gastroenterology , inflammation , obesity , environmental health

Metabolic syndrome (MetS) is a primary risk factor for cardiovascular disease and is associated with a proinflammatory state. Here, we assessed the contribution of inflammatory and oxidative stress markers towards prediction of MetS. A total of 2316 individuals were recruited in Phase I of the Indian Atherosclerosis Research Study (IARS). Modified ATPIII guidelines were used for classification of subjects with MetS. Among the inflammatory and oxidative stress markers studied, levels of hsCRP (P<.0001), Neopterin (P=.036), and oxLDL (P<.0001) were significantly higher among subjects with MetS. Among the markers we tested, oxLDL stood out as a robust predictor of MetS in the IARS population (OR 4.956 95% CI 2.504–9.810; P<.0001) followed by hsCRP (OR 1.324 95% CI 1.070–1.638; P=.010). In conclusion, oxLDL is a candidate predictor for MetS in the Asian Indian population

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