Open AccessClinical Utility of Serum Interleukin-8 and Interferon-Alpha in Thyroid Diseases
Author(s) -
Toral P. Kobawala,
Girish H. Patel,
Dhara R. Gajjar,
Kamini N. Patel,
Premal B. Thakor,
Urvi B. Parekh,
K. M. Patel,
Shilin N. Shukla,
Pankaj Shah
Publication year - 2011
Publication title -
journal of thyroid research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 31
eISSN - 2090-8067
pISSN - 2042-0072
DOI - 10.4061/2011/270149
Subject(s) - medicine , thyroid , disease , stage (stratigraphy) , pathogenesis , thyroid disease , alpha interferon , interferon , gastroenterology , thyroid cancer , interferon γ , immunology , interferon gamma , cytokine , paleontology , biology
Serum interleukin-8 (IL-8) and interferon-alpha (IFN-α) levels have been estimated from a total of 88 individuals of which 19 were disease-free healthy individuals, and 69 were patients with thyroid diseases: goitre (N=21), autoimmune diseases (N=16), and carcinomas (N=32). Both IL-8 and IFN-α were significantly higher in all the patients as compared to healthy individuals. Serum IL-8 levels showed significant positive correlation with disease stage in thyroid cancer patients. Higher serum IL-8 levels were associated with advanced disease stage while no significant correlation was observed between serum IFN-α levels and any of the clinicopathological parameters. IL-8 and IFN-α significantly correlated with each other in anaplastic carcinoma patients. Finally concluding, monitoring the serum IL-8 and IFN-α levels can help differentiate patients with thyroid diseases from healthy individuals, and IL-8 seems to have a role in the pathogenesis of thyroid diseases and may represent a target for innovative diagnostic and therapeutic strategies
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