Validated RP-HPLC Method for the Determination of Buspirone in Pharmaceutical Formulations | Zendy

M. V. Basaveswara Rao | Zendy; A. V. D. Nagendrakumar | Zendy; Sushanta Maiti | Zendy; Guttikonda Raja | Zendy

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Validated RP-HPLC Method for the Determination of Buspirone in Pharmaceutical Formulations

Author(s) -

M. V. Basaveswara Rao,

A. V. D. Nagendrakumar,

Sushanta Maiti,

Guttikonda Raja

Publication year - 2011

Publication title -

chromatography research international

Language(s) - English

Resource type - Journals

eISSN - 2090-3510

pISSN - 2090-3502

DOI - 10.4061/2011/232505

Subject(s) - buspirone , chromatography , acetonitrile , high performance liquid chromatography , chemistry , analytical chemistry (journal) , materials science , biochemistry , receptor , agonist

A simple, selective, linear, precise, and accurate RP-HPLC method was developed and validated for the rapid assay of the Buspirone in tablet dosage form. Isocratic elution at a flow rate of 1.0 mL/min was employed on a symmetry C18 (250×4.6 mm, 5 μm in particle size) at ambient temperature. The mobile phase consisted of water : acetonitrile : methanol 45 : 35 : 20(V/V). The UV detection wavelength was 210 nm, and 20 μL sample was injected. The retention time for the Buspirone was 7.057 min. The percentage RSD for precision and accuracy of the method was found to be less than 2%. The method was validated as per the ICH guidelines. The method can be successfully applied for the routine analysis of Buspirone in tablet dosage form

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