Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target | Zendy

Maciej Jankowski | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target

Author(s) -

Maciej Jankowski

Publication year - 2011

Publication title -

enzyme research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.439

H-Index - 39

eISSN - 2090-0406

pISSN - 2090-0414

DOI - 10.4061/2011/194857

Subject(s) - autotaxin , lysophosphatidic acid , melanoma , receptor , extracellular , biology , cancer research , microbiology and biotechnology , cancer , biochemistry , genetics

Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA1-LPA6) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research