Why Can Insulin Resistance Be a Natural Consequence of Thyroid Dysfunction? | Zendy

Gabriela Brenta | Zendy

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Why Can Insulin Resistance Be a Natural Consequence of Thyroid Dysfunction?

Author(s) -

Gabriela Brenta

Publication year - 2011

Publication title -

journal of thyroid research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 31

eISSN - 2090-8067

pISSN - 2042-0072

DOI - 10.4061/2011/152850

Subject(s) - hormone , insulin resistance , medicine , thyroid , endocrinology , insulin , thyroid hormones , carbohydrate metabolism , thyroid dysfunction , metabolism

Evidence for a relationship between T4 and T3 and glucose metabolism appeared over 100 years ago when the influence of thyroid hormone excess in the deterioration of glucose metabolism was first noticed. Since then, it has been known that hyperthyroidism is associated with insulin resistance. More recently, hypothyroidism has also been linked to decreased insulin sensitivity. The explanation to this apparent paradox may lie in the differential effects of thyroid hormones at the liver and peripheral tissues level. The purpose of this paper is to explore the effects of thyroid hormones in glucose metabolism and analyze the mechanisms whereby alterations of thyroid hormones lead to insulin resistance.

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