Thyroid Hormone Action in Cerebellum and Cerebral Cortex Development | Zendy

Fabrice Chatonnet | Zendy; Frédéric Picou | Zendy; Teddy Fauquier | Zendy; Frédéric Flamant | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Thyroid Hormone Action in Cerebellum and Cerebral Cortex Development

Author(s) -

Fabrice Chatonnet,

Frédéric Picou,

Teddy Fauquier,

Frédéric Flamant

Publication year - 2011

Publication title -

journal of thyroid research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.457

H-Index - 31

eISSN - 2090-8067

pISSN - 2042-0072

DOI - 10.4061/2011/145762

Subject(s) - hormone , transcription factor , thyroid , neuroscience , thyroid hormones , brain development , medicine , nuclear receptor , receptor , cerebellum , gene , endocrinology , biology , biochemistry

Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,3,5-triiodo-L-thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain. T3 activates a number of differentiation processes in neuronal and glial cell types by binding to nuclear receptors, acting directly on transcription. Only few T3 target genes are currently known. Deeper investigations are urgently needed, considering that some chemicals present in food are believed to interfere with T3 signaling with putative neurotoxic consequences

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research