The Survival Strategies of Malaria Parasite in the Red Blood Cell and Host Cell Polymorphisms
Author(s) -
Gunanidhi Dhangadamajhi,
Shantanu Kumar Kar,
Manoranjan Ranjit
Publication year - 2010
Publication title -
malaria research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.726
H-Index - 15
eISSN - 2090-8075
pISSN - 2044-4362
DOI - 10.4061/2010/973094
Subject(s) - malaria , parasite hosting , host (biology) , biology , gene , plasmodium (life cycle) , cell , hemoglobin , evolutionary biology , immunology , genetics , biochemistry , computer science , world wide web
Parasite growth within the erythrocyte causes dramatic alterations of host cell which on one hand facilitates nutrients acquisition from extracellular environment and on other hand contributes to the symptoms of severe malaria. The current paper focuses on interactions between the Plasmodium parasite and its metabolically highly reduced host cell, the natural selection of numerous polymorphisms in the genes encoding hemoglobin and other erythrocyte proteins
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