The Roles of Several Residues of Escherichia coli DNA Photolyase in the Highly Efficient Photo‐Repair of Cyclobutane Pyrimidine Dimers | Zendy

Lei Xu | Zendy; Guoping Zhu | Zendy

Open Access

The Roles of Several Residues of Escherichia coli DNA Photolyase in the Highly Efficient Photo‐Repair of Cyclobutane Pyrimidine Dimers

Author(s) -

Lei Xu,

Guoping Zhu

Publication year - 2010

Publication title -

journal of nucleic acids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.621

H-Index - 32

eISSN - 2090-021X

pISSN - 2090-0201

DOI - 10.4061/2010/794782

Subject(s) - pyrimidine dimer , photolyase , escherichia coli , cyclobutane , pyrimidine , dna , dna repair , chemistry , computational biology , genetics , biology , biochemistry , gene , organic chemistry , ring (chemistry)

Escherichia coli DNA photolyase is an enzyme that repairs the major kind of UV-induced lesions, cyclobutane pyrimidine dimer (CPD) in DNA utilizing 350-450 nm light as energy source. The enzyme has very high photo-repair efficiency (the quantum yield of the reaction is ~0.85), which is significantly greater than many model compounds that mimic photolyase. This suggests that some residues of the protein play important roles in the photo-repair of CPD. In this paper, we have focused on several residues discussed their roles in catalysis by reviewing the existing literature and some hypotheses.

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