Phases I–III Clinical Trials Using Adult Stem Cells | Zendy

Ricardo Sanz-Ruíz | Zendy; Enrique Gutiérrez | Zendy; Adolfo Villa | Zendy; María Eugenia FernándezSantos | Zendy; Pedro L. Sánchez | Zendy; Francisco FernándezAvilés | Zendy

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Phases I–III Clinical Trials Using Adult Stem Cells

Author(s) -

Ricardo Sanz-Ruíz,

Enrique Gutiérrez,

Adolfo Villa,

María Eugenia FernándezSantos,

Pedro L. Sánchez,

Francisco FernándezAvilés

Publication year - 2010

Publication title -

stem cells international

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.205

H-Index - 64

eISSN - 1687-9678

pISSN - 1687-966X

DOI - 10.4061/2010/579142

Subject(s) - clinical trial , medicine , stem cell , myocardial ischemia , randomized controlled trial , disease , intensive care medicine , ischemia , cardiology , bioinformatics , biology , genetics

First randomized clinical trials have demonstrated that stem cell therapy can improve cardiac recovery after the acute phase of myocardial ischemia and in patients with chronic ischemic heart disease. Nevertheless, some trials have shown that conflicting results and uncertainties remain in the case of mechanisms of action and possible ways to improve clinical impact of stem cells in cardiac repair. In this paper we will examine the evidence available, analyze the main phase I and II randomized clinical trials and their limitations, discuss the key points in the design of future trials, and depict new directions of research in this fascinating field.

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