Open AccessGrape-Seed Polyphenolic Extract Improves the Eye Phenotype in aDrosophilaModel of Tauopathy
Author(s) -
Cathie M. Pfleger,
Jun Wang,
Lauren G. Friedman,
Roselle Vittorino,
Lindsay Conley,
Lap Ho,
Hayley C. Fivecoat,
Giulio Maria Pasinetti
Publication year - 2010
Publication title -
international journal of alzheimer s disease
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.657
H-Index - 49
eISSN - 2090-8024
pISSN - 2090-0252
DOI - 10.4061/2010/576357
Subject(s) - tauopathy , drosophila (subgenus) , phenotype , neurodegeneration , medicine , polyphenol , disease , biology , neuroscience , bioinformatics , computational biology , genetics , pathology , biochemistry , gene , antioxidant
Drosophila models of tauopathies have been developed by transgenically overexpressing the disease-associated forms of tau. In this paper we report for the first time that a recently developed Grape-Seed Polyphenolic Extract (GSPE) improves the eye phenotype of a Drosophila eye model of R406W tau. GSPE-mediated improvements in this distinct in vivo neurodegeneration model for protein misfolding/aggregation suggest that GSPE may have therapeutic value in disorders involving aberrant protein aggregation.
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