Synthesis and G‐Quadruplex‐Binding Properties of Defined Acridine Oligomers | Zendy

Rubén Ferreira | Zendy; Anna Aviñó | Zendy; Ricardo PérezTomás | Zendy; Raimundo Gargallo | Zendy; Ramón Eritja | Zendy

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Synthesis and G‐Quadruplex‐Binding Properties of Defined Acridine Oligomers

Author(s) -

Rubén Ferreira,

Anna Aviñó,

Ricardo PérezTomás,

Raimundo Gargallo,

Ramón Eritja

Publication year - 2010

Publication title -

journal of nucleic acids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.621

H-Index - 32

eISSN - 2090-021X

pISSN - 2090-0201

DOI - 10.4061/2010/489060

Subject(s) - acridine , g quadruplex , computer science , chemistry , combinatorial chemistry , dna , biochemistry , organic chemistry

The synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase methodology is described. Subsequent studies on cell viability showed that these compounds are not cytotoxic. Binding to several DNA structures was studied by competitive dialysis, which showed a clear affinity for DNA sequences that form G-quadruplexes and parallel triplexes. The fluorescence spectra of acridine oligomers were affected strongly upon binding to DNA. These spectral changes were used to calculate the binding constants (K). Log K were found to be in the order of 4-6.

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