The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism | Zendy

Donna M. Gordon | Zendy; Janine Hertzog Santos | Zendy

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The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism

Author(s) -

Donna M. Gordon,

Janine Hertzog Santos

Publication year - 2010

Publication title -

journal of nucleic acids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.621

H-Index - 32

eISSN - 2090-021X

pISSN - 2090-0201

DOI - 10.4061/2010/390791

Subject(s) - telomere , telomerase , reverse transcriptase , mitochondrial dna , telomerase reverse transcriptase , mitochondrion , dna , biology , microbiology and biotechnology , nuclear dna , computational biology , rna , genetics , gene

Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a role in mitochondrial DNA metabolism. This paper discusses the available data on mitochondrial telomerase with particular emphasis on its effects upon the organellar DNA.

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