Nonhomologous DNA End Joining in Cell‐Free Extracts | Zendy

Sheetal Sharma | Zendy; Sathees C. Raghavan | Zendy

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Nonhomologous DNA End Joining in Cell‐Free Extracts

Author(s) -

Sheetal Sharma,

Sathees C. Raghavan

Publication year - 2010

Publication title -

journal of nucleic acids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.621

H-Index - 32

eISSN - 2090-021X

pISSN - 2090-0201

DOI - 10.4061/2010/389129

Subject(s) - non homologous end joining , dna , computer science , computational biology , genetics , biology , dna repair

Among various DNA damages, double-strand breaks (DSBs) are considered as most deleterious, as they may lead to chromosomal rearrangements and cancer when unrepaired. Nonhomologous DNA end joining (NHEJ) is one of the major DSB repair pathways in higher organisms. A large number of studies on NHEJ are based on in vitro systems using cell-free extracts. In this paper, we summarize the studies on NHEJ performed by various groups in different cell-free repair systems.

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