Open AccessReview of Temephos Discriminating Concentration for Monitoring the Susceptibility of Anopheles labranchiae (Falleroni, 1926), Malaria Vector in Morocco
Author(s) -
Chafika Faraj,
El Bachir Adlaoui,
M. Elkohli,
T. Herrak,
Btissam Ameur,
Fabrice Chandre
Publication year - 2010
Publication title -
malaria research and treatment
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.726
H-Index - 15
eISSN - 2090-8075
pISSN - 2044-4362
DOI - 10.4061/2010/126085
Subject(s) - malaria , larva , veterinary medicine , anopheles , biology , toxicology , vector (molecular biology) , medicine , ecology , immunology , biochemistry , gene , recombinant dna
In Morocco, the resistance monitoring of Anopheles labranchiae larvae to temephos is done using discriminating concentration of 0.125 mg, which is half of the WHO recommended dose for Anopheles. However, this dosage seemed to be too high to allow an early detection of the resistance and its revision was found necessary. The present study was carried out during May-June 2008 and 2009 in nine provinces from the north-west of the country. The aim was to determine the lethal concentrations LC100 of temephos for the most susceptible populations and to define the discriminating dosage as the double of this value. The bioassays were conducted according to WHO standard operating protocol to establish the dose-mortality relationship and deduct the LC50 and LC95. The results of this study indicated that the LC100 obtained on the most susceptible populations was close to 0.05 mg/l. Therefore, the temephos discriminating dosage for susceptibility monitoring of An. labranchiae larvae in Morocco was set to be 0.1 mg/l
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom