Open AccessCoronary Artery Disease: A Study on the Joint Role of Birth Weight, Adenosine Deaminase, and Gender
Author(s) -
F. GloriaBottini,
Maria Banci,
P. Saccucci,
N. Lucarini,
Francesca Ianniello,
Giancarlo Paradisi,
Andrea Magrini,
E. Bottini
Publication year - 2009
Publication title -
cardiology research and practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 35
eISSN - 2090-8016
pISSN - 2090-0597
DOI - 10.4061/2009/860328
Subject(s) - medicine , adenosine deaminase , coronary artery disease , odds ratio , birth weight , genotype , artery , allele , physiology , cardiology , adenosine , pregnancy , genetics , biology , gene
An inverse relationship between birth weight and coronary artery diseases is well documented but it remains unclear which exposure in early life might underlie such association. Recently it has been reported an association between adenosine deaminase genetic polymorphism and coronary artery diseases. Gender differences in the degree of this association have been also observed. These observations prompted us to study the possible joint effects of BW, ADA, and gender on the susceptibility to coronary artery diseases. 222 subjects admitted to hospital for nonfatal coronary artery diseases, and 762 healthy consecutive newborns were studied. ADA genotypes were determined by DNA analysis. A highly significant complex relationship has emerged among ADA, birth weight, and gender concerning their role on susceptibility to coronary artery diseases in adult life. Odds ratio analysis suggests that low birth weight is more important in females than in males. ADA ∗ 2 allele appears protective in males, while in females such effect is obscured by birth weight.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom