Complete genome sequence of Treponema pallidum strain DAL-1 | Zendy

Marie Zobaníková | Zendy; Pavol Mikolka | Zendy; Darina Čejková | Zendy; Petra Pospíšilová | Zendy; Lei Chen | Zendy; Michal Strouhal | Zendy; Xiang Qin | Zendy; George M. Weinstock | Zendy; David Šmajs | Zendy

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Complete genome sequence of Treponema pallidum strain DAL-1

Author(s) -

Marie Zobaníková,

Pavol Mikolka,

Darina Čejková,

Petra Pospíšilová,

Lei Chen,

Michal Strouhal,

Xiang Qin,

George M. Weinstock,

David Šmajs

Publication year - 2012

Publication title -

standards in genomic sciences

Language(s) - English

Resource type - Journals

ISSN - 1944-3277

DOI - 10.4056/sigs.2615838

Subject(s) - treponema , whole genome sequencing , strain (injury) , biology , virulence , syphilis , genome , genetics , pathogen , virology , gene , anatomy , human immunodeficiency virus (hiv)

Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.

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