The Mononuclear Phagocyte System of the Rat | Zendy

David Hume | Zendy; Melanie Caruso | Zendy; Sahar Keshvari | Zendy; Omkar L. Patkar | Zendy; Anuj Sehgal | Zendy; Stephen J. Bush | Zendy; Kim Summers | Zendy; Clare Pridans | Zendy; Katharine M. Irvine | Zendy

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The Mononuclear Phagocyte System of the Rat

Author(s) -

David Hume,

Melanie Caruso,

Sahar Keshvari,

Omkar L. Patkar,

Anuj Sehgal,

Stephen J. Bush,

Kim Summers,

Clare Pridans,

Katharine M. Irvine

Publication year - 2021

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.2100136

Subject(s) - mononuclear phagocyte system , phagocyte , immunology , biology , phagocytosis

The laboratory rat continues to be the model of choice for many studies of physiology, behavior, and complex human diseases. Cells of the mononuclear phagocyte system (MPS; monocytes, macrophages, and dendritic cells) are abundant residents in every tissue in the body and regulate postnatal development, homeostasis, and innate and acquired immunity. Recruitment and proliferation of MPS cells is an essential component of both initiation and resolution of inflammation. The large majority of current knowledge of MPS biology is derived from studies of inbred mice, but advances in technology and resources have eliminated many of the advantages of the mouse as a model. In this article, we review the tools available and the current state of knowledge of development, homeostasis, regulation, and diversity within the MPS of the rat.

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