Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to the Draining Lymph Node | Zendy

Juliana Bernardi Aggio | Zendy; Veronika Krmeská | Zendy; Brian J. Ferguson | Zendy; Pryscilla Fanini Wowk | Zendy; Antonio Gigliotti Rothfuchs | Zendy

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Vaccinia Virus Infection Inhibits Skin Dendritic Cell Migration to the Draining Lymph Node

Author(s) -

Juliana Bernardi Aggio,

Veronika Krmeská,

Brian J. Ferguson,

Pryscilla Fanini Wowk,

Antonio Gigliotti Rothfuchs

Publication year - 2021

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.2000928

Subject(s) - vaccinia , lymph node , virology , virus , smallpox , immunology , lymph , medicine , biology , microbiology and biotechnology , vaccination , pathology , biochemistry , gene , recombinant dna

Key PointsReplication-competent VACV inhibits skin DC migration to draining lymph node. The VACV-suppressive effect is a general phenomenon of VACV infection in the skin. VACV can access the lymph node in the absence of DC transport and prime CD4 + T cells.

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