Overcoming Waning Immunity in Pertussis Vaccines: Workshop of the National Institute of Allergy and Infectious Diseases | Zendy

F. Heath Damron | Zendy; Mariette Barbier | Zendy; Purnima Dubey | Zendy; Kathryn M. Edwards | Zendy; XinXing Gu | Zendy; Nicola P. Klein | Zendy; Kristina T. Lu | Zendy; Kingston H. G. Mills | Zendy; Marcela F. Pasetti | Zendy; Robert C. Read | Zendy; Pejman Rohani | Zendy; Peter Šebo | Zendy; Eric T. Harvill | Zendy

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Overcoming Waning Immunity in Pertussis Vaccines: Workshop of the National Institute of Allergy and Infectious Diseases

Author(s) -

F. Heath Damron,

Mariette Barbier,

Purnima Dubey,

Kathryn M. Edwards,

XinXing Gu,

Nicola P. Klein,

Kristina T. Lu,

Kingston H. G. Mills,

Marcela F. Pasetti,

Robert C. Read,

Pejman Rohani,

Peter Šebo,

Eric T. Harvill

Publication year - 2020

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.2000676

Subject(s) - bordetella pertussis , immunity , medicine , pertussis vaccine , immunology , whooping cough , infectious disease (medical specialty) , virology , disease , vaccination , immunization , biology , antibody , immune system , pathology , genetics , bacteria

Despite high vaccine coverage in many parts of the world, pertussis is resurging in a number of areas in which acellular vaccines are the primary vaccine administered to infants and young children. This is attributed in part to the suboptimal and short-lived immunity elicited by acellular pertussis vaccines and to their inability to prevent nasal colonization and transmission of the etiologic agent Bordetella pertussis In response to this escalating public health concern, the National Institute of Allergy and Infectious Diseases held the workshop "Overcoming Waning Immunity in Pertussis Vaccines" in September 2019 to identify issues and possible solutions for the defects in immunity stimulated by acellular pertussis vaccines. Discussions covered aspects of the current problem, gaps in knowledge and possible paths forward. This review summarizes presentations and discussions of some of the key points that were raised by the workshop.

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