Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms | Zendy

Adam McNee | Zendy; Trevor R.F. Smith | Zendy; Barbara Holzer | Zendy; Becky Clark | Zendy; Emily Bessell | Zendy; Ghiabe-Henri Guibinga | Zendy; Heather Brown | Zendy; Katherine Schultheis | Zendy; Paul D. Fisher | Zendy; Stephanie J. Ramos | Zendy; Alejandro Núñez | Zendy; Matthieu Bernard | Zendy; Simon P. Graham | Zendy; Veronica Martini | Zendy; Tiphany Chrun | Zendy; Yongli Xiao | Zendy; John C. Kash | Zendy; Jeffery K. Taubenberger | Zendy; Sarah T. C. Elliott | Zendy; Ami Patel | Zendy; Peter C. L. Beverley | Zendy; Pramila Rijal | Zendy; David B. Weiner | Zendy; Alain Townsend | Zendy; Kate E. Broderick | Zendy; Elma Tchilian | Zendy

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Establishment of a Pig Influenza Challenge Model for Evaluation of Monoclonal Antibody Delivery Platforms

Author(s) -

Adam McNee,

Trevor R.F. Smith,

Barbara Holzer,

Becky Clark,

Emily Bessell,

Ghiabe-Henri Guibinga,

Heather Brown,

Katherine Schultheis,

Paul D. Fisher,

Stephanie J. Ramos,

Alejandro Núñez,

Matthieu Bernard,

Simon P. Graham,

Veronica Martini,

Tiphany Chrun,

Yongli Xiao,

John C. Kash,

Jeffery K. Taubenberger,

Sarah T. C. Elliott,

Ami Patel,

Peter C. L. Beverley,

Pramila Rijal,

David B. Weiner,

Alain Townsend,

Kate E. Broderick,

Elma Tchilian

Publication year - 2020

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.2000429

Subject(s) - monoclonal antibody , hemagglutinin (influenza) , virology , vaccination , pandemic , virus , viral load , influenza a virus subtype h5n1 , medicine , immunology , biology , antibody , covid-19 , pathology , infectious disease (medical specialty) , disease

Key PointsNeutralizing mAb 2–12C reduces influenza viral load and lung pathology in pigs. DNA plasmid–encoded 2–12C reduces lung pathology. The pig is a useful preclinical model for testing mAbs and mAb delivery platforms.

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