The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation | Zendy

Bin Xie | Zendy; Tariq Khoyratty | Zendy; Enas AbuShah | Zendy; Pablo F. Céspedes | Zendy; Andrew J. MacLean | Zendy; Gabriela Pirgova | Zendy; Zhiyuan Hu | Zendy; Ahmed A. Ahmed | Zendy; Michael L. Dustin | Zendy; Irina A. Udalova | Zendy; Tal I. Ar | Zendy

Open Access

The Zinc Finger Protein Zbtb18 Represses Expression of Class I Phosphatidylinositol 3-Kinase Subunits and Inhibits Plasma Cell Differentiation

Author(s) -

Bin Xie,

Tariq Khoyratty,

Enas AbuShah,

Pablo F. Céspedes,

Andrew J. MacLean,

Gabriela Pirgova,

Zhiyuan Hu,

Ahmed A. Ahmed,

Michael L. Dustin,

Irina A. Udalova,

Tal I. Ar

Publication year - 2021

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.2000367

Subject(s) - pi3k/akt/mtor pathway , zinc finger , repressor , enhancer , biology , microbiology and biotechnology , transcription factor , phosphatidylinositol , transcriptional regulation , signal transduction , kinase , gene , genetics

Key PointsThe Zinc finger protein, Zbtb18, is downregulated during PC differentiation. Enhanced expression of Zbtb18 leads to impaired PC development. Zbtb18 directly binds and inhibits expression of PI3K subunits.

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