Neuronal Regulation of Cutaneous Immunity | Zendy

Jonathan Cohen | Zendy; Jianing Wu | Zendy; Daniel H. Kaplan | Zendy

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Neuronal Regulation of Cutaneous Immunity

Author(s) -

Jonathan Cohen,

Jianing Wu,

Daniel H. Kaplan

Publication year - 2020

Publication title -

the journal of immunology

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1901109

Subject(s) - innate immune system , neuroscience , immune system , context (archaeology) , biology , immunity , neuroimmunology , sensory system , pattern recognition receptor , secretion , inflammation , innate lymphoid cell , immunology , paleontology , biochemistry

The skin is innervated by numerous sensory afferent neurons that respond to a diverse array of stimuli ranging from gentle touch to noxious pain. Various features of the immune system-pathogen recognition, secretion of soluble mediators-are shared with the nervous system. This has led to the recognition that neurons share some functions with innate immune cells and have the capacity to recognize pathogens and participate in innate immune responses. Neuroimmune interactions are bidirectional. Soluble mediators from immune cells activate neurons and soluble mediators from neurons can activate immune cells. In this review, we will focus on the interplay between neurons and innate immunity in the skin in the context of host defense and inflammation.

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