Open AccessThe Surprising Discovery That TGFβ Specifically Induces the IgA Class Switch
Author(s) -
Janet Stavnezer,
Joonsoo Kang
Publication year - 2009
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.182.1.5
Subject(s) - class (philosophy) , immunoglobulin class switching , transforming growth factor , microbiology and biotechnology , biology , genetics , computer science , antibody , artificial intelligence , b cell
The two Pillars of Immunology articles in this issue ([1][1], [2][2]) were the first to demonstrate that IgA switching is induced by TGFβ. In 1989, when these two important papers were published, it was known that IL-4 directs LPS-activated B cells to switch to IgG1 and IgE ([3][3], [4][4], [5][5
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