Macrophages as APC and the Dendritic Cell Myth | Zendy

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Macrophages as APC and the Dendritic Cell Myth

Author(s) -

David Hume

Publication year - 2008

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.181.9.5829

Subject(s) - antigen presentation , cd11c , mononuclear phagocyte system , dendritic cell , microbiology and biotechnology , antigen presenting cell , lineage (genetic) , macrophage , cd40 , immunology , biology , immune system , presentation (obstetrics) , phagocyte , follicular dendritic cells , t cell , medicine , cytotoxic t cell , phenotype , genetics , gene , in vitro , radiology

Dendritic cells have been considered an immune cell type that is specialized for the presentation of Ag to naive T cells. Considerable effort has been applied to separate their lineage, pathways of differentiation, and effectiveness in Ag presentation from those of macrophages. This review summarizes evidence that dendritic cells are a part of the mononuclear phagocyte system and are derived from a common precursor, responsive to the same growth factors (including CSF-1), express the same surface markers (including CD11c), and have no unique adaptation for Ag presentation that is not shared by other macrophages.

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