Thymic Emigration: When and How T Cells Leave Home | Zendy

Michael Weinreich | Zendy; Kristin A. Hogquist | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Thymic Emigration: When and How T Cells Leave Home

Author(s) -

Michael Weinreich,

Kristin A. Hogquist

Publication year - 2008

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.181.4.2265

Subject(s) - thymocyte , biology , microbiology and biotechnology , immune system , cd8 , t cell , transcription factor , cytotoxic t cell , immunology , genetics , gene , in vitro

The thymus supports the differentiation of multiple distinct T cell subsets that play unique roles in the immune system. CD4 and CD8 alpha/beta T cells, gamma/delta T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus and must leave it to provide their functions elsewhere in the body. This article will review recent research indicating differences in the time and migration patterns of T cell subsets found in the thymus. Additionally, we review current understanding of the molecules involved in thymocyte emigration, including the sphingolipid receptor S1P(1) and its regulation by the Krüppel-like transcription factor KLF2.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research