Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys | Zendy

José C. Crispín | Zendy; Mohamed Oukka | Zendy; George Bayliss | Zendy; Robert A. Cohen | Zendy; Christine A. Van Beek | Zendy; Isaac E. Stillman | Zendy; Vasileios C. Kyttaris | Zendy; YuangTaung Juang | Zendy; George C. Tsokos | Zendy

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Expanded Double Negative T Cells in Patients with Systemic Lupus Erythematosus Produce IL-17 and Infiltrate the Kidneys

Author(s) -

José C. Crispín,

Mohamed Oukka,

George Bayliss,

Robert A. Cohen,

Christine A. Van Beek,

Isaac E. Stillman,

Vasileios C. Kyttaris,

YuangTaung Juang,

George C. Tsokos

Publication year - 2008

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.181.12.8761

Subject(s) - lupus nephritis , autoantibody , immunology , pathogenesis , kidney , medicine , systemic lupus erythematosus , lupus erythematosus , pathology , antibody , disease

Double negative (DN) T cells are expanded in patients with systemic lupus erythematosus (SLE) and stimulate autoantibody production as efficiently as CD4(+) T cells. In this study, we demonstrate that DN T cells from patients with SLE produce significant amounts of IL-17 and IFN-gamma, and expand when stimulated in vitro with an anti-CD3 Ab in the presence of accessory cells. Furthermore, IL-17(+) and DN T cells are found in kidney biopsies of patients with lupus nephritis. Our findings establish that DN T cells produce the inflammatory cytokines IL-17 and IFN-gamma, and suggest that they contribute to the pathogenesis of kidney damage in patients with SLE.

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