Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid | Zendy

Hilde Brouwers | Zendy; Hulda S. Jónasdóttir | Zendy; Marije E. Kuipers | Zendy; Joanneke C. Kwekkeboom | Zendy; Jennifer L. Auger | Zendy; Mayra I. Gonzalez-Torres | Zendy; Cristina LópezVicario | Zendy; J. J. Clariá | Zendy; Jona Freysdóttir | Zendy; Ingibjörg Harðardóttir | Zendy; José GarridoMesa | Zendy; Lucy V. Norling | Zendy; Mauro Perretti | Zendy; T. Huizinga | Zendy; M. Kloppenburg | Zendy; René E. M. Toes | Zendy; Bryce A. Binstadt | Zendy; Martin Giera | Zendy; Andreea IoanFacsinay | Zendy

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Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid

Author(s) -

Hilde Brouwers,

Hulda S. Jónasdóttir,

Marije E. Kuipers,

Joanneke C. Kwekkeboom,

Jennifer L. Auger,

Mayra I. Gonzalez-Torres,

Cristina LópezVicario,

J. J. Clariá,

Jona Freysdóttir,

Ingibjörg Harðardóttir,

José GarridoMesa,

Lucy V. Norling,

Mauro Perretti,

T. Huizinga,

M. Kloppenburg,

René E. M. Toes,

Bryce A. Binstadt,

Martin Giera,

Andreea IoanFacsinay

Publication year - 2020

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1801653

Subject(s) - leukotriene b4 , polyunsaturated fatty acid , arachidonic acid , inflammation , proinflammatory cytokine , arthritis , efferocytosis , in vivo , chemistry , biochemistry , biology , pharmacology , fatty acid , immunology , macrophage , in vitro , enzyme , microbiology and biotechnology

Polyunsaturated fatty acids (PUFAs) and their metabolites are potent regulators of inflammation. Generally, omega ( n )-3 PUFAs are considered proresolving whereas n -6 PUFAs are classified as proinflammatory. In this study, we characterized the inflammatory response in murine peritonitis and unexpectedly found the accumulation of adrenic acid (AdA), a poorly studied n -6 PUFA. Functional studies revealed that AdA potently inhibited the formation of the chemoattractant leukotriene B 4 (LTB 4 ), specifically in human neutrophils, and this correlated with a reduction of its precursor arachidonic acid (AA) in free form. AdA exposure in human monocyte-derived macrophages enhanced efferocytosis of apoptotic human neutrophils. In vivo, AdA treatment significantly alleviated arthritis in an LTB 4 -dependent murine arthritis model. Our findings are, to our knowledge, the first to indicate that the n -6 fatty acid AdA effectively blocks production of LTB 4 by neutrophils and could play a role in resolution of inflammation in vivo.

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