IL-17 in Renal Immunity and Autoimmunity | Zendy

Partha S. Biswas | Zendy

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IL-17 in Renal Immunity and Autoimmunity

Author(s) -

Partha S. Biswas

Publication year - 2018

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1801042

Subject(s) - autoimmunity , immunology , proinflammatory cytokine , inflammation , immunity , context (archaeology) , medicine , kidney , cytokine , immune system , neutrophil extracellular traps , biology , paleontology

The kidney is an organ particularly susceptible to damage caused by infections and autoimmune conditions. Renal inflammation confers protection against microbial infections. However, if unchecked, unresolved inflammation may lead to kidney damage. Although proinflammatory cytokine IL-17 is required for immunity against extracellular pathogens, dysregulated IL-17 response is also linked to autoimmunity. In this review, we will discuss the current knowledge of IL-17 activity in the kidney in context to renal immunity and autoimmunity and raise the intriguing question to what extent neutralization of IL-17 is beneficial or harmful to renal inflammation.

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