NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death | Zendy

Katarina Radulović | Zendy; Cemil Korcan Ayata | Zendy; Rachel Mak’Anyengo | Zendy; Kristina Lechner | Zendy; Philipp Wuggenig | Zendy; Berna Kaya | Zendy; Petr Hrúz | Zendy; Mercedes Gomez de Agüero | Zendy; Petr Brož | Zendy; Benno Weigmann | Zendy; Jan Hendrik Niess | Zendy

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NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death

Author(s) -

Katarina Radulović,

Cemil Korcan Ayata,

Rachel Mak’Anyengo,

Kristina Lechner,

Philipp Wuggenig,

Berna Kaya,

Petr Hrúz,

Mercedes Gomez de Agüero,

Petr Brož,

Benno Weigmann,

Jan Hendrik Niess

Publication year - 2019

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.1800938

Subject(s) - pyrin domain , nod , inflammasome , receptor , innate immune system , adoptive cell transfer , biology , microbiology and biotechnology , pattern recognition receptor , immune system , t cell , programmed cell death , immunology , inflammation , apoptosis , endocrinology , biochemistry , diabetes mellitus

The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6 -deficient T cells following adoptive transfer into Rag2 -deficient mice, indicating tha Nlrp6 deficiency in CD4 + T cells led to decreased survival.

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