Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus | Zendy

Katie Foster | Zendy; Julie M. Sheridan | Zendy; Henrique VeigaFernandes | Zendy; Kathleen Roderick | Zendy; Vassilis Pachnis | Zendy; Ralf H. Adams | Zendy; Clare Blackburn | Zendy; Dimitris Kioussis | Zendy; Mark Coles | Zendy

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Contribution of Neural Crest-Derived Cells in the Embryonic and Adult Thymus

Author(s) -

Katie Foster,

Julie M. Sheridan,

Henrique VeigaFernandes,

Kathleen Roderick,

Vassilis Pachnis,

Ralf H. Adams,

Clare Blackburn,

Dimitris Kioussis,

Mark Coles

Publication year - 2008

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.180.5.3183

Subject(s) - mesenchyme , neural crest , sox10 , embryonic stem cell , microbiology and biotechnology , mesenchymal stem cell , biology , fetus , anatomy , pathology , embryo , medicine , pregnancy , genetics , biochemistry , gene

Neural crest (NC)-derived mesenchyme has previously been shown to play an important role in the development of fetal thymus. Using Wnt1-Cre and Sox10-Cre mice crossed to Rosa26(eYfp) reporter mice, we have revealed NC-derived mesenchymal cells in the adult murine thymus. We report that NC-derived cells infiltrate the thymus before day 13.5 of embryonic development (E13.5) and differentiate into cells with characteristics of smooth muscle cells associated with large vessels, and pericytes associated with capillaries. In the adult organ at 3 mo of age, these NC-derived perivascular cells continue to be associated with the vasculature, providing structural support to the blood vessels and possibly regulating endothelial cell function.

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