Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression | Zendy

Laura Strauss | Zendy; Christoph Bergmann | Zendy; Mirosław J. Szczepański | Zendy; Stephan Lang | Zendy; John M. Kirkwood | Zendy; Theresa L. Whiteside | Zendy

Open Access

Expression of ICOS on Human Melanoma-Infiltrating CD4+CD25highFoxp3+ T Regulatory Cells: Implications and Impact on Tumor-Mediated Immune Suppression

Author(s) -

Laura Strauss,

Christoph Bergmann,

Mirosław J. Szczepański,

Stephan Lang,

John M. Kirkwood,

Theresa L. Whiteside

Publication year - 2008

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.180.5.2967

Subject(s) - flow cytometry , regulatory t cell , immune system , il 2 receptor , peripheral blood mononuclear cell , cancer research , immunology , melanoma , t cell , foxp3 , biology , chemistry , microbiology and biotechnology , in vitro , biochemistry

Interaction of ICOS with its ligand (ICOSL, B7-H2) promotes T cell responses. As CD4+CD25highFoxp3+ naturally occurring T regulatory cells in melanoma patients express ICOS, we investigated the impact of ICOS on naturally occurring T regulatory cell function.

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