Mechanisms for Decreased Function of B Cells in Aged Mice and Humans | Zendy

Daniela Frasca | Zendy; Ana Marie Landin | Zendy; Richard L. Riley | Zendy; Bonnie B. Blomberg | Zendy

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Mechanisms for Decreased Function of B Cells in Aged Mice and Humans

Author(s) -

Daniela Frasca,

Ana Marie Landin,

Richard L. Riley,

Bonnie B. Blomberg

Publication year - 2008

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.180.5.2741

Subject(s) - tristetraprolin , cytidine deaminase , immune system , immunoglobulin class switching , biology , lymphocyte , immunology , microbiology and biotechnology , function (biology) , transcription factor , b cell , messenger rna , antibody , genetics , gene , untranslated region

The immune system has been known for some time to be compromised in aged individuals, e.g., both mice and humans, and in both humoral and cellular responses. Our studies have begun to elucidate intrinsic B lymphocyte defects in Ig class switch recombination, activation-induced cytidine deaminase, and E47 transcription factor expression. These defects occur in both mice and humans. Our studies have also shown that tristetraprolin is one of the key players in regulating the decreased E47 mRNA stability in aged B lymphocytes. These and current studies should lead to improvements in B lymphocyte function in aged populations.

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