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The 1975 publication by Gus Nossal and Bev Pike ([1][1]), reprinted as a Pillars of Immunology article in this issue of The Journal of Immunology , reads as an elegant and compelling set of experiments viewed through the “retrospectroscope.” However, in 1975, and indeed for the next 13 years,

Nossal and Pike 1975: A Turning Point in the Effort to Define Self-Tolerance Mechanisms