IL-21 Induces Apoptosis of Antigen-Specific CD8+ T Lymphocytes | Zendy

Brianne R. Barker | Zendy; Jenny G. Parvani | Zendy; Debra Meyer | Zendy; Adam Hey | Zendy; Kresten Skak | Zendy; Norman L. Letvin | Zendy

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IL-21 Induces Apoptosis of Antigen-Specific CD8+ T Lymphocytes

Author(s) -

Brianne R. Barker,

Jenny G. Parvani,

Debra Meyer,

Adam Hey,

Kresten Skak,

Norman L. Letvin

Publication year - 2007

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.179.6.3596

Subject(s) - cd8 , cytotoxic t cell , cytokine , apoptosis , secretion , biology , immunology , microbiology and biotechnology , interleukin 15 , antigen , interleukin , endocrinology , in vitro , genetics

IL-21, a member of the common gamma-chain family of cytokines, has pleiotropic effects on T, B, and NK cells. We found that IL-21 and the prototype common gamma-chain cytokine IL-2 can stimulate proliferation and cytokine secretion by Ag-specific rhesus monkey CD8+ T cells. However, unique among the members of this family of cytokines, we found that IL-21 drives these cells to apoptosis by down-regulation of Bcl-2. These findings suggest that IL-21 may play an important role in the contraction of CD8+ T cell responses.

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