Cutting Edge: Tlr5−/− Mice Are More Susceptible to Escherichia coli Urinary Tract Infection | Zendy

Erica AndersenNissen | Zendy; Thomas R. Hawn | Zendy; Kelly D. Smith | Zendy; Alex Nachman | Zendy; Aaron Lampano | Zendy; Satoshi Uematsu | Zendy; Shizuo Akira | Zendy; Alan Aderem | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Cutting Edge: Tlr5−/− Mice Are More Susceptible to Escherichia coli Urinary Tract Infection

Author(s) -

Erica AndersenNissen,

Thomas R. Hawn,

Kelly D. Smith,

Alex Nachman,

Aaron Lampano,

Satoshi Uematsu,

Shizuo Akira,

Alan Aderem

Publication year - 2007

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.178.8.4717

Subject(s) - tlr5 , flagellin , innate immune system , immune system , biology , microbiology and biotechnology , chemokine , escherichia coli , inflammation , immunology , in vivo , bacteria , toll like receptor , gene , biochemistry , genetics

Although TLR5 regulates the innate immune response to bacterial flagellin, it is unclear whether its function is essential during in vivo murine infections. To examine this question, we challenged Tlr5(-/-) mice transurethrally with Escherichia coli. At 2 days postinfection, wild-type mice exhibited increased inflammation of the bladder in comparison to Tlr5(-/-) mice. By day 5 postinfection, Tlr5(-/-) mice had significantly more bacteria in the bladders and kidneys in comparison to wild-type mice and showed increased inflammation in both organs. In addition, flagellin induced high levels of cytokine and chemokine expression in the bladder that was dependent on TLR5. Together, these data represent the first evidence that TLR5 regulates the innate immune response in the urinary tract and is essential for an effective murine in vivo immune response to an extracellular pathogen.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research