Variability and Exclusion in Host and Parasite: Epigenetic Regulation of Ig and var Expression | Zendy

Shira Fraenkel | Zendy; Yehudit Bergman | Zendy

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Variability and Exclusion in Host and Parasite: Epigenetic Regulation of Ig and var Expression

Author(s) -

Shira Fraenkel,

Yehudit Bergman

Publication year - 2006

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.177.9.5767

Subject(s) - parasite hosting , epigenetics , biology , host (biology) , expression (computer science) , genetics , evolutionary biology , zoology , gene , computer science , programming language , world wide web

The immune system generates highly diverse AgRs of different specificities from a pool of designated genomic loci, each containing large arrays of genes. Ultimately, each B or T cell expresses a receptor of a single type on its surface. Immune evasion by the malaria parasite Plasmodium falciparum is mediated by the mutually exclusive expression of a single member of the var family of genes, which encodes variant surface Ags. In this review, we discuss the similarities as well as the unique characteristics of the epigenetic mechanisms involved in the establishment of mutually exclusive expression in the immune and parasite systems.

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