Follistatin-Like Protein-1 Is a Novel Proinflammatory Molecule | Zendy

Takako Miyamae | Zendy; Anthony Marinov | Zendy; Dawn P. Sowders | Zendy; David C. Wilson | Zendy; Jason Devlin | Zendy; Robert M. Boudreau | Zendy; Paul D. Robbins | Zendy; Raphael Hirsch | Zendy

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Follistatin-Like Protein-1 Is a Novel Proinflammatory Molecule

Author(s) -

Takako Miyamae,

Anthony Marinov,

Dawn P. Sowders,

David C. Wilson,

Jason Devlin,

Robert M. Boudreau,

Paul D. Robbins,

Raphael Hirsch

Publication year - 2006

Publication title -

the journal of immunology

Language(s) - Hungarian

Resource type - Journals

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.177.7.4758

Subject(s) - follistatin , proinflammatory cytokine , chemistry , immunology , medicine , microbiology and biotechnology , biology , inflammation

While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws during early arthritis, especially at the interface of synovial pannus and eroding bone. In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts leads to up-regulation of proinflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6. Overexpression of FSTL-1 in mouse paws by gene transfer results in severe paw swelling and arthritis.

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