Protection from Abortion by Heme Oxygenase-1 Up-Regulation Is Associated with Increased Levels of Bag-1 and Neuropilin-1 at the Fetal-Maternal Interface | Zendy

André Sollwedel | Zendy; Annarosa Zambon Bertoja | Zendy; María Laura Zenclussen | Zendy; Katrin Gerlof | Zendy; Ulrike Lisewski | Zendy; Paul O. Wafula | Zendy; Birgit Sawitzki | Zendy; Christian Woiciechowsky | Zendy; HansDieter Volk | Zendy; Ana Claudia Zenclussen | Zendy

Open Access

Protection from Abortion by Heme Oxygenase-1 Up-Regulation Is Associated with Increased Levels of Bag-1 and Neuropilin-1 at the Fetal-Maternal Interface

Author(s) -

André Sollwedel,

Annarosa Zambon Bertoja,

María Laura Zenclussen,

Katrin Gerlof,

Ulrike Lisewski,

Paul O. Wafula,

Birgit Sawitzki,

Christian Woiciechowsky,

HansDieter Volk,

Ana Claudia Zenclussen

Publication year - 2005

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.175.8.4875

Subject(s) - heme oxygenase , abortion , neuropilin 1 , fetus , interface (matter) , heme , chemistry , medicine , pregnancy , biology , biochemistry , vegf receptors , genetics , vascular endothelial growth factor , enzyme , pulmonary surfactant , gibbs isotherm

Tolerance mechanisms allowing pregnancy success resemble those involved in allograft acceptance. Heme oxygenase (HO) is a tissue-protective molecule, which allows graft acceptance and is known to have antiapoptotic effects on several cell types. We previously reported down-regulated levels of HO-1 and HO-2 in placenta from allopregnant mice undergoing abortion. In this study, we analyzed whether the up-regulation of HO-1 by cobalt-protoporphyrin (Co-PP) during implantation window can rescue mice from abortion. Induction of HO-1 by Co-PP treatment prevented fetal rejection, whereas the down-regulation of HOs by zinc-protoporphyrin application boosted abortion. The beneficial effect of HO-1 induction was not related to a local shift to Th2-profile or to a change in the NO system. Interestingly, the expression of the antiapoptotic/cytoprotective molecule Bag-1 as well as the levels of neuropilin-1, a novel marker for T regulatory cells, were up-regulated after Co-PP treatment. Our data strongly support a very important role for HO-1 in fetal allotolerance and suggest that HO-1 might be protective by up-regulating tissue protective molecules, i.e., Bag-1, and by activating T regulatory cells rather than by changing the local cytokine profile.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research