Virus-Induced Inhibition of CD1d1-Mediated Antigen Presentation: Reciprocal Regulation by p38 and ERK | Zendy

Gourapura J. Renukaradhya | Zendy; Tonya J. Webb | Zendy; Masood Alam Khan | Zendy; Yin Lin | Zendy; Wenjun Du | Zendy; Jacquelyn GervayHague | Zendy; Randy R. Brutkiewicz | Zendy

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Virus-Induced Inhibition of CD1d1-Mediated Antigen Presentation: Reciprocal Regulation by p38 and ERK

Author(s) -

Gourapura J. Renukaradhya,

Tonya J. Webb,

Masood Alam Khan,

Yin Lin,

Wenjun Du,

Jacquelyn GervayHague,

Randy R. Brutkiewicz

Publication year - 2005

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.175.7.4301

Subject(s) - vesicular stomatitis virus , antigen presentation , lymphocytic choriomeningitis , biology , mapk/erk pathway , microbiology and biotechnology , immune system , virus , transfection , virology , immunology , t cell , signal transduction , cell culture , cd8 , genetics

A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediated Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.

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