Heat Shock Protein-70 Mediates the Cytoprotective Effect of Carbon Monoxide: Involvement of p38β MAPK and Heat Shock Factor-1 | Zendy

Hong Pyo Kim | Zendy; Xue Wang | Zendy; Jinglan Zhang | Zendy; Gee Young Suh | Zendy; Ivor J. Benjamin | Zendy; Stefan W. Ryter | Zendy; Augustine M.K. Choi | Zendy

Open Access

Heat Shock Protein-70 Mediates the Cytoprotective Effect of Carbon Monoxide: Involvement of p38β MAPK and Heat Shock Factor-1

Author(s) -

Hong Pyo Kim,

Xue Wang,

Jinglan Zhang,

Gee Young Suh,

Ivor J. Benjamin,

Stefan W. Ryter,

Augustine M.K. Choi

Publication year - 2005

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.175.4.2622

Subject(s) - cytoprotection , hsp70 , heat shock protein , heme oxygenase , p38 mitogen activated protein kinases , in vivo , tumor necrosis factor alpha , shock (circulatory) , microbiology and biotechnology , in vitro , chemistry , heme , mapk/erk pathway , heat shock , pharmacology , biology , immunology , medicine , signal transduction , biochemistry , oxidative stress , gene , enzyme

Carbon monoxide (CO), a product of heme oxygenase activity, exerts antiapoptotic and anti-inflammatory effects in vitro and in vivo. The anti-inflammatory effects of CO involve the inhibition of TNF-alpha expression and the enhancement of IL-10 production, resulting in reduced mortality after endotoxin challenge. In this study we demonstrate for the first time that the protective effects of CO involve the increased expression of the 70-kDa inducible heat shock protein (Hsp70) in murine lung endothelial cells and fibroblasts. The p38beta MAPK mediated the effects of CO on cytoprotection and Hsp70 regulation. Suppression of Hsp70 expression and/or genetic deletion of heat shock factor-1, the principle transcriptional regulator of Hsp70, attenuated the cytoprotective and immunomodulatory effects of CO in mouse lung cells and in vivo. These data provide a novel mechanism for the protective effects of CO and underscore a potential application of this gaseous molecule in anti-inflammatory therapies.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research