Oxidized Phospholipids Negatively Regulate Dendritic Cell Maturation Induced by TLRs and CD40 | Zendy

Stephan Blüml | Zendy; Stefanie Kirchberger | Zendy; Valery N. Bochkov | Zendy; Gerhard Krönke | Zendy; Karl M. Stuhlmeier | Zendy; Otto Majdic | Zendy; Gerhard J. Zlabinger | Zendy; Walter Knapp | Zendy; Bernd R. Binder | Zendy; Johannes Stöckl | Zendy; Norbert Leitinger | Zendy

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Oxidized Phospholipids Negatively Regulate Dendritic Cell Maturation Induced by TLRs and CD40

Author(s) -

Stephan Blüml,

Stefanie Kirchberger,

Valery N. Bochkov,

Gerhard Krönke,

Karl M. Stuhlmeier,

Otto Majdic,

Gerhard J. Zlabinger,

Walter Knapp,

Bernd R. Binder,

Johannes Stöckl,

Norbert Leitinger

Publication year - 2005

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.175.1.501

Subject(s) - cd80 , cd86 , cd40 , microbiology and biotechnology , immune system , receptor , dendritic cell , biology , cytokine , chemistry , t cell , immunology , biochemistry , cytotoxic t cell , in vitro

Maturation of dendritic cells (DCs) induced by pathogen-derived signals via TLRs is a crucial step in the initiation of an adaptive immune response and therefore has to be well controlled. In this study, we demonstrate that oxidized phospholipids (ox-PLs), which are generated during infections, apoptosis, and tissue damage, interfere with DC activation, preventing their maturation. ox-PLs blocked TLR-3- and TLR-4-mediated induction of the costimulatory molecules CD40, CD80, CD83, and CD86, the cytokines IL-12 and TNF, as well as lymphocyte stimulatory capacity. CD40 and TLR-2-mediated cytokine production was also inhibited, whereas up-regulation of costimulatory molecules via these receptors was not affected by ox-PLs. Thus, formation of ox-PLs during the course of an inflammatory response may represent a negative-feedback loop preventing excessive and sustained immune reactions through regulating DC maturation.

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