Lymphotoxin-β Receptor-Dependent Genes in Lymph Node and Follicular Dendritic Cell Transcriptomes | Zendy

Christoph Huber | Zendy; Caroline Thielen | Zendy; Harald Seeger | Zendy; Petra Schwarz | Zendy; Fabio Montrasio | Zendy; Mark R. Wilson | Zendy; Ernst Heinen | Zendy; YangXin Fu | Zendy; Gino Miele | Zendy; Adriano Aguzzi | Zendy

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Lymphotoxin-β Receptor-Dependent Genes in Lymph Node and Follicular Dendritic Cell Transcriptomes

Author(s) -

Christoph Huber,

Caroline Thielen,

Harald Seeger,

Petra Schwarz,

Fabio Montrasio,

Mark R. Wilson,

Ernst Heinen,

YangXin Fu,

Gino Miele,

Adriano Aguzzi

Publication year - 2005

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.174.9.5526

Subject(s) - lymphotoxin , germinal center , biology , lymphotoxin beta receptor , transcriptome , follicular dendritic cells , microbiology and biotechnology , gene , receptor , gene expression , genetics , immune system , b cell , t cell , antibody , antigen presenting cell

Affinity maturation and Ab class switches occur in lymphoid germinal centers (GCs), in which differentiation and maintenance depend on lymphotoxin (LT) signaling and include differentiation of follicular dendritic cells (FDCs). The events leading to FDC and GC maturation are poorly defined. Using several approaches of functional genomics, we enumerated transcripts affected in mice by suppressing LT beta receptor (LTbetaR) signaling and/or overrepresented in FDC-enriched GC isolates. Protein expression analysis of 3 of 12 genes both enriched in FDCs and down-regulated by LTbetaR signaling suppression validated them as FDC markers. Functional analysis of one of these three, clusterin, suggests a role as an FDC-derived trophic factor for GC B cells. Hence, the set of genes presented in this study includes markers emanating from LTbetaR signaling and transcripts relevant to GC and FDC function.

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