Open AccessProving Negative Selection in the Thymus
Author(s) -
Jonathan Sprent
Publication year - 2005
Publication title -
the journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.737
H-Index - 372
eISSN - 1550-6606
pISSN - 0022-1767
DOI - 10.4049/jimmunol.174.7.3841
Subject(s) - negative selection , self tolerance , selection (genetic algorithm) , ontogeny , positive selection , biology , psychology , immunology , computer science , t cell , artificial intelligence , genetics , gene , genome , immune system
Today, the idea that many self-reactive T cells are destroyed during ontogeny in the thymus seems almost self-evident. Yet proving this concept of “central tolerance,” or “negative selection,” was surprisingly difficult and depended upon a remarkable piece of detective work by the Kappler/
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