Leptin in Immunology | Zendy

Giuseppe Matarese | Zendy; Stergios Moschos | Zendy; Christos S. Mantzoros | Zendy

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Leptin in Immunology

Author(s) -

Giuseppe Matarese,

Stergios Moschos,

Christos S. Mantzoros

Publication year - 2005

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.174.6.3137

Subject(s) - leptin , adipokine , energy homeostasis , cytokine , proinflammatory cytokine , immune system , homeostasis , immunology , pathophysiology , biology , medicine , endocrinology , inflammation , obesity

Leptin is an adipokine which conveys information on energy availability. In humans, leptin influences energy homeostasis and regulates neuroendocrine function primarily in states of energy deficiency. As a cytokine, leptin also affects thymic homeostasis and, similar to other proinflammatory cytokines, leptin promotes Th1 cell differentiation and cytokine production. We review herein recent advances on the role of leptin in the pathophysiology of immune responses.

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