Sonic Hedgehog Is Produced by Follicular Dendritic Cells and Protects Germinal Center B Cells from Apoptosis | Zendy

Rosa Sacedón | Zendy; B. Simons Diez | Zendy; Vanesa Nuñez | Zendy; Carmen HernándezLópez | Zendy; Cruz GutierrezFrías | Zendy; Teresa Cejalvo | Zendy; Susan V. Outram | Zendy; Tessa Crompton | Zendy; A. Zapata | Zendy; Ángeles Vicente | Zendy; Alberto Varas | Zendy

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Sonic Hedgehog Is Produced by Follicular Dendritic Cells and Protects Germinal Center B Cells from Apoptosis

Author(s) -

Rosa Sacedón,

B. Simons Diez,

Vanesa Nuñez,

Carmen HernándezLópez,

Cruz GutierrezFrías,

Teresa Cejalvo,

Susan V. Outram,

Tessa Crompton,

A. Zapata,

Ángeles Vicente,

Alberto Varas

Publication year - 2005

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.174.3.1456

Subject(s) - smoothened , germinal center , sonic hedgehog , microbiology and biotechnology , hedgehog signaling pathway , patched , follicular dendritic cells , hedgehog , biology , apoptosis , immune system , b cell , t cell , signal transduction , immunology , antigen presenting cell , antibody , biochemistry

The Hedgehog (Hh) signaling pathway is involved in the development of many tissues during embryogenesis, but has also been described to function in adult self-renewing tissues. In the immune system, Sonic Hedgehog (Shh) regulates intrathymic T cell development and modulates the effector functions of peripheral CD4(+) T cells. In this study we investigate whether Shh signaling is involved in peripheral B cell differentiation in mice. Shh is produced by follicular dendritic cells, mainly in germinal centers (GCs), and GC B cells express both components of the Hh receptor, Patched and Smoothened. Blockade of the Hh signaling pathway reduces the survival, and consequently the proliferation and Ab secretion, of GC B cells. Furthermore, Shh rescues GC B cells from apoptosis induced by Fas ligation. Taken together, our data suggest that Shh is one of the survival signals provided by follicular dendritic cells to prevent apoptosis in GC B cells.

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