TGF-α Regulates TLR Expression and Function on Epidermal Keratinocytes | Zendy

Lloyd Miller | Zendy; Ole E. Sørensen | Zendy; Philip T. Liu | Zendy; H. Ray Jalian | Zendy; Deborah Eshtiaghpour | Zendy; Behnaz E. Behmanesh | Zendy; Woosin Chung | Zendy; Timothy D. Starner | Zendy; Jenny Kim | Zendy; Peter A. Sieling | Zendy; Tomas Ganz | Zendy; Robert L. Modlin | Zendy

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TGF-α Regulates TLR Expression and Function on Epidermal Keratinocytes

Author(s) -

Lloyd Miller,

Ole E. Sørensen,

Philip T. Liu,

H. Ray Jalian,

Deborah Eshtiaghpour,

Behnaz E. Behmanesh,

Woosin Chung,

Timothy D. Starner,

Jenny Kim,

Peter A. Sieling,

Tomas Ganz,

Robert L. Modlin

Publication year - 2005

Publication title -

the journal of immunology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.737

H-Index - 372

eISSN - 1550-6606

pISSN - 0022-1767

DOI - 10.4049/jimmunol.174.10.6137

Subject(s) - tlr5 , tlr9 , microbiology and biotechnology , epidermis (zoology) , transforming growth factor , function (biology) , biology , toll like receptor , keratinocyte , innate immune system , immune system , immunology , gene expression , cell culture , gene , anatomy , genetics , dna methylation

The expression of TLRs on epithelial cells provides a first line of defense against invading pathogens. We investigated the regulated expression and function of TLR5 and TLR9 on human keratinocytes, because we found by immunohistochemistry that these TLRs are expressed in distinct layers of the epidermis. We found that TGF-alpha, a growth and differentiation factor that is present during wound healing and in psoriasis, increased the expression of both TLR5 and TLR9 on keratinocytes. In addition, TGF-alpha regulated the function of TLR5 and TLR9, because activation with their respective ligands enhanced the production of IL-8 and human beta-defensins. These findings provide evidence that TGF-alpha up-regulates TLR expression and function, augmenting host defense mechanisms at epithelial surfaces.

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